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In addition, TCM can promote the synthesis of key synthetic enzymes of SCFAs to elevate the level of SCFAs, or mediate SCFAs to regulate energy metabolism and inflammation-related pathways to improve LMD

Using a holistic approach to treatment can lead to improvement in sleep quality and duration

One example is the case of the novel acylaminoimidazole derivative, 2-[mesityl(methyl)amino]-N-[4-(pyridin-2-yl)-1H-imidazol-2-yl] acetamide trihydrochloride (WN1316) that proved to upregulate Nrf2 and regulate GSH, protecting motor neurons against OS [170] (Figure 3)