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Available from: Krupa KN, Fritz K, Parmar M

March 14 Product: BMSs Breyanzi Indications: chronic lymphocytic leukemia and small lymphocytic leukemia As Bristol Myers Squibb made final preparations for Fridays advisory committee meeting on its CAR-T therapy Abecma, the company got an early win in the same drug class

The calculation for the loading dose is based on the formula published by van Groningen et al (2010) as follows: Vitamin D Loading dose (IU) = 45 multiplied by the desired rise in vitamin D level (target vitamin D level starting vitamin D level in ng/mL) multiplied by body weight in pounds

The recently completed Phase 3 TRIUMPH-4 trial confirmed this, showing 28.7% average weight loss (71.2 lbs) at 68 weeks with the weekly 12 mg dose