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Second, we identified that expression of SLC7A11 , a key component of system x C that imports cystine for the formation of GSH, is a novel and robust predictive biomarker of tumour response to APR-246

[PUBMED Abstract] Bhojwani D, Sabin ND, Pei D, et al.: Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia