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10.1038/cr.2014.75 Cell Res

Moreover, preclinical RF models exhibit significant limitations: UUO and I/R models induce acute severe fibrosis that does not mimic the gradual progression of human CKD-related RF and lacks comorbidities (e.g., diabetes and hypertension) that are common in clinical settings

Other oral medications with narrow therapeutic windows medications such as certain thyroid medications, oral antibiotics, and other drugs that depend on consistent gastric absorption timing may be affected