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These structures are stabilized by various interactions between amino acid side chains, including hydrogen bonds, ionic bonds, hydrophobic interactions, and disulfide bridges

Unlike homocysteine, which responds to both B12 and folate intake, the metabolite methylmalonic acid (MMA) specifically responds to B12 intake, and for some time we viewed MMA levels as the most important measure of B12 activity

Decreased NAD + levels can impair the efficiency of the mitochondrial respiratory chain, resulting in reduced energy production, which may exacerbate obesity and related metabolic disorders (Amjad et al., 2021)