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In this paper, a subclass of -gliadins genes, encoding proteins that cause food IgE-mediated allergy, were silenced in order to decrease the level of 5-gliadins in grain

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150,151,152,153 In animal models with reduced F/B ratios, the expression of mucin and ZO-1 in the intestinal barrier, as well as the expression of anti-inflammatory factors, is increased, whereas the expression of the proinflammatory cytokines TNF-, IL-1, and IL-6 is inhibited, and disease symptoms are largely reversed