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Isogenic transplantation may be "autologous" if the transferred cells are obtained and transplanted into the same subject

1985 - 1991 Copyright Copyright The Authors 2014 Oxidative stress is defined as an increased generation of reactive oxygen species or a reduced ability to deactivate them

Importantly, these residues, including His27, Lys59 and Tyr63 in LET7 TPR mediating polar interactions with HOP1, reside on the key interaction interface with LET7 PPase in the crystal structure of LET7/ At PAPP5 (PDB ID: 7OBE) 25 , further substantiating the idea that HOP1 displaces LET7 TPR from LET7 PPase to relieve the autoinhibition of LET7 catalytic activity

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