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Description

This stress activates the PEAK-HSPA5-GPX4 signaling axis, involving upregulation of PERK, activation of ATF4, and subsequent induction of HSPA5

BMC Complement Altern Med 17:111

Discussion Our study was primarily aimed at characterizing the mechanisms by which cancer cells adapt to methionine depletion caused by the catalytic activity of MGL, a potentially powerful drug that impairs their proliferation and viability