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Dean OM, van den Buuse M, Berk M, Copolov DL, Mavros C, Bush AI

Cell Metab (2016) 24(3):44761

Secondly, we have summarized the molecular mechanisms underlying intestinal barrier damage (Table 1)

What they found: NR is rapidly absorbed orally , peak at 30 minutes NR is converted to NAD+ in multiple tissues , liver, muscle, blood Plasma NAD+ rises 2 to 8 after a single dose Optimal dosing regimens: 100 to 1000 mg No accumulation of toxic metabolites Why it matters: This is the reference pharmacokinetic publication for NR and NMN