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Simultaneously, the TCA cycle is activated and this activation may be associated with the entry of BCAA metabolites into the TCA cycle, thereby providing tumor cells with energy and metabolic intermediates [150]

Furthermore, the peptide ApoE-DBCO, capable of specifically binding to LDLR expressed on brain endothelial cells and glioma cells, was coupled to the azido group of nanoprobe through a Cu-free click cycloaddition reaction