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Over the following weeks most people notice subtle metabolic shifts and reduced bloating first (weeks 12), then more noticeable body-composition change around the midsection (weeks 24), then visible fat loss with muscle preserved (weeks 48), with the best results from week 8 onward, diet and exercise still do the heavy lifting

Once-Weekly Semaglutide in Adults with Overweight or Obesity, The New England Journal of Medicine, John P.H

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References References Selective and membranepermeable small molecule inhibitors of NNMT Roles of Nicotinamide NMethyltransferase in Obesity and Type 2 Diabetes Nicotinamide Nmethyltransferase inhibition mimics and boosts exercisemediated improvements in muscle function in aged mice Reduced calorie diet combined with NNMT inhibition establishes a healthier gut microbiome in obese mice Kraus et al