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Tumor promoter-induced sulfiredoxin is required for mouse skin tumorigenesis

Among ROS, peroxynitrite is mainly responsible for the oxidation of both BH4 and BH2

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This analogue also demonstrated the most pronounced detoxifying effect towards cisplatin action, resulting in a decrease in the animal death from the acute cisplatin toxicity to 17% (in comparison with 50-67% for the control animals) and restoration of a number of cisplatin-sensitive biochemical blood parameters: decrease in the activity of aspartate aminotransferase and alanine aminotransferase and downregulation of the concentration of the final products of nitrogen exchange (creatinine and urea)