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J Clin Oncol 1992;10:116570

Complex III can also generate O 2 and release it into the intermembrane space where the O 2 traverses through voltage-dependent anion channels (VDACs) into the cytosol and is converted into H 2 O 2 by SOD1

Recent studies have highlighted how perturbations in iron metabolism and oxidative stress responses contribute to both the development and suppression of malignancies