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In reality, methylation depends on cellular energy, mitochondrial one-carbon metabolism, amino-acid handling, redox balance and the removal of homocysteine and adenosine

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However, in a Phase III trial involved 143 patients, pre-administration of oral pregabalin (flexible daily doses of 150600 mg) during oxaliplatin infusion did not improve chronic pain, as well as the life quality and mood of the cancer patients [57]