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Responsible breeders have an inherent responsibility to breed healthy dogs

Clinical observations indicated that caution should be exercised when prescribing antidepressants, as misuse could lead to or worsen metabolic dysregulation (254, 255)

They are sold pre-mixed, but there are good reasons to keep them separate: their half-lives and the quantities used differ substantially, so a fixed blend forces one schedule and one ratio onto two compounds that suit different ones

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