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The pathogenesis of PCOS involves oxidative stress as a fundamental factor which disrupts follicular development while inducing granulosa cell apoptosis and promoting insulin resistance (33)

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Iron plays a direct and causal role in the pathogenesis of diabetes mediated by -Cell exhaustion and insulin resistance (Simcox and McClain, 2013), even in the absence of apparent iron overload (Vari et al., 2007), thus precise control of iron levels in the body is critical for maintaining metabolic homeostasis (Wang et al., 2021)

Effects of long-term whole-body cold exposures on plasma concentrations of ACTH, beta-endorphin, cortisol, catecholamines and cytokines in healthy females