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[DOI] [PMC free article] [PubMed] [Google Scholar] 110.Oettel L, Kubisch I, Wohmann N, et al

However, these steady-state measures do not define metabolic flux of the molecule of interest i.e., the rate of production and depletion

We also provide an update on the targets and clinical prospects of different antioxidants (melatonin, N-acetylcysteine, vitamins, -lipoic acid, mineral elements, phytochemicals, nutritional antioxidants, cytoprotectants and synthetic compounds) in the treatment of CIPN with the help of preclinical and clinical studies, emphasizing the great potential of antioxidants as adjuvant strategies to mitigate CIPN

For instance, via RNA-RNA interactions the CaP-overexpressed lncRNA PCLN16 stabilizes mRNA of HIP1, leading to increased expression of this AR-associated coregulator and a positive feedback loop to augment AR signaling [133]