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The responses were recorded from the needle and cap electrodes (filtering frequency of 10 Hz to 10 kHz, sensitivity of 2 mV/division, and sweep speed of 1 ms/division) by means of an electromyographic recorder (Negarandishegan, Iran)

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On the one hand, activation of HIF-1 in osteoblasts has been shown to suppress osteoclastogenesis by upregulating osteoprotegerin (OPG) and interleukin-33 (IL-33), thereby inhibiting the RANKL/Notch1 signaling pathway (Kang et al., 2017)

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