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3.2 Liver Diseases Mitochondrial FAO is the primary pathway for FA metabolism and performs a key role for energy homeostasis in the liver (Li and Davie, 2010

as a condition that can progress to cirrhosis without consumption of significant alcohol ( Several years later, the term MASLD was proposed, and its diagnosis can be done based on the patient meeting one of five cardiovascular risk factors, unlike MAFLD, which underlines a requirement that the patients meet two of seven parameters of metabolic dysfunction ( The severe form of MASLD is MASH, a replacement of the term non-alcoholic steatohepatitis (NASH), characterized by the presence of lobular inflammation and ballooning of hepatocytes and is associated with a greater risk of fibrosis progression (Figure 1)

Similarly, zone 3 predominant hepatic steatosis is reported in adult NAFLD patients [28]

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