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Several coexisting conditions may falsely lower serum B 12 levels, including oral contraceptive use, multiple myeloma, pregnancy, and folate deficiency

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The phenomenon was first recognized during phase I/II studies, when the plasma of all daratumumab-treated MM patients demonstrated false-positive antibody screens and pan-reactivity on RBC-panel testing for up to 6 months after treatment discontinuation [46, 47]