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It has been shown to induce apoptosis by activating pro-apoptotic proteins (e.g., Bax, p53) and inhibiting antiapoptotic factors (e.g., Bcl-2) (38)

However, the proteins identified as differentially expressed between non-splenectomized -thalassemia/HbE patients and healthy volunteers included a number of cytoskeletal proteins (F-actin -capping protein subunit beta, myosin light polypeptide 6, myosin regulatory light chain 12A, myosin-9, Rho GDP-dissociation inhibitor 2, transgelin-2, PDZ and LIM domain protein 1, and tropomyosin alpha-4 chain) as well as heat shock protein 70 kDa protein, integrin alpha IIb, beta-2-microglobulin, hemoglobin subunit beta, platelet factor 4 (or chemokine (C-X-C motif) and leukocyte elastase inhibitor

These compounds have been investigated for the treatment of rheumatoid arthritis, renal injuries, gastric cancer, lung cancer, and other diseases (Yang et al., 2023)

Section 1886(d)(13)(B) of the Act requires the Secretary to use data the Secretary determines to be appropriate to establish the qualifying counties