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This leads to the accumulation of excess oxygen radicals, contributing to oxidative stress and further triggering CSD ( At the cellular level, CSD can incite neuroinflammation through a series of interactions involving the pannexin-1 channel, caspase-1, interleukin (IL) 1, and high-mobility group box 1 in neurons

Since Glutathione helps slow down melanin synthesis and supports skin cell renewal, it can gradually lighten the darker pigmentation caused by sun exposure

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Hence, NO and its regulatory factor, active oxygen, such as O 2 , may control a variety of physiological reactions