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References Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al

PARP is another significant NAD+ consumer that becomes more active when DNA damage builds up

(110) showed that endogenously generated NO and ROS contribute to HIF-1 accumulation by inhibiting prolyl hydroxylase domain proteins (PHDs) via S-nitrosation of PHD2, thus preventing HIF-1 degradation during hypoxia (110)