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Bone marrow transplants restored the levels of these substances, indicating that the presence of CD4 T-lymphocytes alter microglial and astroglial activation in ALS and may support motor neuron protection by modulating the glial balance between trophism and cytotoxicity [27]

It should be noted that renal senescence can also occur in sick children and may reduce their renal regeneration potential (Melk et al., 2009)

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