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(-)-Vestitol, Salviolone, and their combination reduced the A plaque burden and toxic soluble A levels in APP/PS1 transgenic mice We examined A deposition in the cortex and hippocampus of the mice

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doi: 10.1016/j.neulet.2017.09.048 59 GmitterovK.HeinemannU.GawineckaJ.VargesD.CiesielczykB.ValkovicP.et al

The FDA's decision to grant orforglipron a Commissioner's National Priority Review Voucher further accelerated the regulatory timeline, potentially compressing the standard 10-12 month review period to as little as 1-2 months