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Int J Diabetes Dev Ctries 34(4):220223 Olaniyan OO, Awonuga MAM, Ajetunmobi AF, Adeleke IA, Fagbolade OJ, Olabiyi KO, Oyekanmi BA, Osadolor HB (2012) Serum copper and zinc levels in Nigerian type 2 diabetic patients

They regulate energy production, neuronal firing, and neuroprotection

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For example, NAPQI, the toxic metabolite, is primarily the product of CYP2E1 metabolism, and there is evidence that younger children have a relative immaturity in CYP2E1 metabolism, which would substantially reduce the production of this toxic metabolite in infants.7 After birth, CYP2E1 protein expression and activity increases, reaching adult levels by about 1 year of age.7 The ability of the liver to metabolize acetaminophen changes with age owing to differences in activity of these key metabolic pathways