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Edgewise Therapeutics is moving into phase III later this year with its oral, selective cardiac sarcomere modulator, EDG-7500, based on strong safety and compelling efficacy data suggesting it could be a strong competitor of cardiac myosin inhibitors in treating hypertrophic cardiomyopathy

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This guide sequence was inserted into the lentiCRISPR v2 Puro plasmid (Derived from Addgene plasmid #83480 by replacing the blasticidin S-resistance gene with a puromycin- resistance gene)

The autoimmune response in Graves disease is often accompanied by increased OS, which exacerbates thyroid tissue damage and may contribute to the development of thyroid eye disease (TED) [79]