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The 2,2-bipyridine may enter mitochondria and chelate mitochondrial iron, therefore decreasing the generation of ROS ( 2+ chelating agent, with coordination properties similar to 2,2-bipyridine

Accumulation of free radicals and increased pro-inflammatory cytokines such as IL-1 and IL-6, combined with decreased expression of anti-inflammatory cytokines such as IL-10 and IL-4, contribute to the maintenance of the senescent inflammatory state (Ye and Johnson, 2001

However, orthopaedic-specific clinical evidence supporting improved healing or postoperative recovery is lacking

The beneficial therapeutic effects of UA in acute and chronic forms of mouse experimental allergic encephalomyelitis (EAE) have also been shown [156]