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Additionally, PTBP1-K436la enhances its RNA-binding affinity and stabilizes PFKFB4 mRNA, boosting glycolysis and, in turn, forming a feedback loop, exacerbating tumorigenesis

An imbalance in the intestinal barrier structure can flare up into an uncontrollable immune reaction in the intestinal microenvironment or allow the unrestrained growth of microbiota, which leads to various diseases, including intestinal inflammatory disorders, extra-intestinal autoimmune diseases such as rheumatoid arthritis and multiple sclerosis, and metabolic disorders such as diabetes and obesity 4,5,6

With aging, accumulated oxidative damage leads to a decline in granulosa cell autophagy

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