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Because swallowing 500 micrograms of cyanocobalamin can result in absorption of as little as 1.8 micrograms, many oral supplements do not provide an adequate daily intake

In 2010, a randomised, placebo-controlled trial was published in the BMJ

The pharmaceutical sector itself accounts for 41.7% of the BWFI application demand, driven by its extensive use in preparing biologics, vaccines, and other research compounds