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For most people these taper off significantly after 4 to 8 weeks

Sheerin and Hiltbrunner 2017

What If My Reconstituted MOTS-c Was Left Out of the Fridge Overnight

the non-enzymatic pathway involves ROS and Fe 2+ -driven Fenton reactions, which induce spontaneous oxidation of PUFA-PLs and further accumulation of PUFA-PL-OOHs (Kwun and Lee, 2023)