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Chronic inflammation leads to cartilage destruction, bone erosion, and progressive joint deformity

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These findings contrast those of Dvl3 null mice, which displayed PCP defects in addition to loss of outer hair cells (Etheridge et al., Dvl3 null mice with one functional allele of Dvl2 exhibits more severe PCP defects than Dvl3 null animals alone, again suggesting Dvl members may complement each others

The most discussed effects are sexual in nature: a subset of users report reduced libido, erectile dysfunction, and ejaculatory changes in approximately two to four percent of users in clinical trials, though real-world reporting and patient advocacy groups suggest this number may undercount persistent cases [6]