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Several animal toxicity studies showed that inflammatory reactions are initiated by the production of interleukin-1 beta (IL-1), interleukin-6 (IL-6), cyclooxygenases (1 and 2) (COX-1, COX-2), and tumor necrosis factor- (TNF-), causing systemic inflammation []

Tetrahydrobiopterin (BH 4 ) eNOS requires several cofactors, such as heme, flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), as well as BH 4 for elicitation of full enzymatic activity