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This study also suggested that those who did not take a supplement containing vitamin B12 were twice as likely to be B12 deficient as supplement users, regardless of age group

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As to topical antibiotics, which, when used together with retinoids, represent a mainstay in acne treatment, when used for a longer time, they lead to the development of antibiotic-resistant strains of bacteria, making them less effective over time [13]

We can't stress this enough: careful measurement is the bedrock of responsible science