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Long-term metformin use and vitamin b12 deficiency in the diabetes prevention program outcomes study

[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Feng L., Ren J., Li Y., Yang G., Kang L., Zhang S., Ma C., Li J., Liu J., Yang L., et al

It declines with age, and lower NAD+ is associated with slower metabolism and the changes we lump together as getting older. NNMT, meanwhile, consumes the raw materials your body uses to make NAD+ and in fat tissue, NNMT is often overexpressed, which can drag NAD+ down right where you least want a sluggish metabolism