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There are a number of reasons related to a persons age, dietary practices, stress levels, exposure to toxins, as well as illnesses, which may lower the bodys natural production of glutathione

10.1371/journal.pone.0006413 PLoS One

Then, through an extensive analysis of in vitro and in vivo studies, we highlight the adverse effects of NBNs exposure, including the generation of reactive oxygen species (ROS), oxidative stress, inflammation, cytotoxicity, genotoxicity, and immunotoxicity