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Specifically, the accumulated copper ions within cells directly bind to lipoylated proteins in the TCA cycle, leading to their inactivation and subsequent cell death (Fig

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, 116 , 2283-2292, doi: Guo, W., Zhao, Y., Zhang, Z., Tan, N., Zhao, F., Ge, C., Liang, L., Jia, D., Chen, T., Yao, M., Li, J., and He, X

P21 reverses this architectural damage while simultaneously generating new neurons to replace those lost entirely