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GlaxoSmithKline (GSK): "Paid a then-record $3 billion settlement in 2012 for promoting common prescription drugs like Paxil and Wellbutrin for unapproved uses, failing to report safety data for Avandia, and paying kickbacks to physicians. Pfizer Accrued around $7.8 billion in financial penalties, with a single 2009 settlement of $2.3 billion for illegal promotion of several drugs, including Bextra, marking the largest criminal fine in U.S

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FDA found no human exposure data for the defined substances, major safety-data gaps and insufficient evidence of wound-healing effectiveness

Peptide therapy requires a valid prescription from a licensed healthcare provider