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Mechanistically, AS occurs in the nucleus following transcription where precursor mRNAs undergo exon and intron removal and ligation, leading to the generation of multiple transcript isoforms with potentially diverse coding capacities [66]

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Furthermore, another study focusing on GC revealed that MACC1 enhances MET expression and stimulates the downstream AKT/mTOR pathway, which consequently leads to increased PD-L1 expression levels in GC [132]

Setting Realistic Expectations Peptide therapy is a long-term strategy, not a quick fix