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Typical administration Mostly, peptides are administered via a subcutaneous route (under the skin)

Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways

The IVD is composed of three substructures: 1) the proteoglycan-rich central region referred to as the nucleus pulposus (NP), 2) the fibrocartilaginous peripheral region referred to as the annulus fibrosus (AF), and 3) the superior and inferior cartilaginous endplates (CEP) (Humzah and Soames, 1988

They decrease pro-inflammatory cytokines such as TNF- and IL-6 and promote reparative M2 macrophage phenotypes that reduce fibrosis and maintain tissue architecture