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The withdrawals/removals included: Placebo Group (11 withdrawals, including 5 due to adverse effects) 4 participants withdrew because their parents lost interest in the study 1 child was removed by the PI due to a change of school 1 participant began behavior medication 1 week into study and was removed by the PI 3 cases of loose stools/ diarrhea (all 3 had gut issues prior to starting, and the continuation of those symptoms caused them to drop out) 1 participant had increased stimming (rubbing face) - history of this, but seemed to worsen 1 participant withdrew due to behavior problems Treatment Group (8 withdrawals, including 3 due to adverse effects) 2 participants were removed from the study because they made changes in their psychiatric medications in the first few weeks of the study

Research suggests taking combined phentermine and topiramate may be more effective than using the drugs separately

Its important to note that while some people seek B12 supplementation for wellness, the benefits in non-deficient individuals are not strongly supported by evidence

Appetite stimulation: Strong, consistent increase in hunger the most reliably reported effect of GHRP-6 [11]