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KPV reduces the inflammatory signaling from chronic hyperglycemia that drives ongoing nerve injury

Its deficiency leads to mitochondrial dysfunction, lactate and pyruvate accumulation, and consequently to focal thalamic degeneration, manifested as Wernickes encephalopathy or WernickeKorsakoff syndrome

This selection is based on the objectives of the study taking into account the physicochemical properties of the fluorophore as well as the characteristics of the sample