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We consistently found that cells expressing gspD regularly secreted AEP, visualized as persistent and thick trails emerging from the cell body, whereas cells depleted for GspD produced very low levels of AEP, or none at all (Fig

(Source: Ribas V, Garca-Ruiz C, Fernndez-Checa JC

Our analyses thus reveal that vesicular fluid-phase transfer through LECs into the subcapsular sinus represents a third major pathway for protein transfer into the stroma of the draining LN (Supplemental Figure 8)