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The combination of GPX4 and CDK4/6 inhibitors is more effective than the single drugs in ER+ and triple negative breast cancer models To further evaluate the potential of targeting GPX4 to enhance CDK4/6 inhibitor sensitivity, we investigated the effect of combining GPX4 inhibitors with palbociclib in a panel of ER+ and RB1 wild type TNBC cell lines

Phosphorylation of HSL and perilipin was also upregulated to drive the delipidation of stable adipocytes in a catecholamine-independent manner

doi: 10.3389/fnagi.2021.674135 Google Scholar Sprenger, HG, Mittenbhler, MJ, Sun, Y et al

However, further research is warranted to establish this fact