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Targeting necroptosis pathways in NAFLD/NASH Targeting the execution process of necroptosis The recognition of necroptosis as a unique PCD mechanism has led to substantial evidence linking it to NAFLD pathogenesis and its transition to NASH and HCC

Silent information regulator 1 (Sirt1), an anti-inflammatory and anti-oxidative protein (316), increases the production of NO by activating endothelial NOS (eNOS) in endothelial cells in response to shear stress (317)