acetaminophen overdose napqi glutathione mechanism authoritative source

acetaminophen overdose napqi glutathione mechanism authoritative source Full article: Paracetamol (acetaminophen) and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease Mini Review Study of Acetaminophen

Name: acetaminophen overdose napqi glutathione mechanism authoritative source Full article: Paracetamol (acetaminophen) and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease Mini Review Study of Acetaminophen
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Mini Review Study of Acetaminophen Overdose Poisoning and Associated Factors in Cases from Poison Acetaminophen (APAP) Toxicity: Clinical Cases, Diagnosis, Pathology, Treatments and Patient Education PPT What is the antidote of choice for acetaminophen poisoning? N acetylcysteine (NAC) Glutathione Answer in the story Acetaminophen metabolism. Acetaminophen is metabolized primarily by sulfation and glucuronidation. However, it can also be oxidized by CYPs to form NAPQI. NAPQI can then interact with cellular macromolecules, resulting in toxicity, or it can be detoxified

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Korsakova, 114 (4), 41-46

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Synthesis of -glutamylcysteine in the chloroplast by GCL directly supports production of glutathione by plastid GS, but requires transport of the dipeptide to the cytosol for the cytosolic GS and movement of glutathione between organelles and the cytosol (Pasternak et al., 2008