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Taurine tissue distribution is characterized by low concentrations of taurine in the plasma and extracellular fluids (ranging from 10 to 100 M) and high intracellular concentrations of taurine reaching up to 50 mM, depending on the cell type (Huxtable 1992

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Once it enters the cytoplasm, glutamine is hydrolyzed to glutamate and ammonia (NH 3 ) via GLS (Fig

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