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The database search was performed in parallel against the Human (taxon id 9606) protein database, which comprised 20,377 sequences extracted from UniProtKB/Swiss-Prot database of Release 2022_01

Human SQOR as well as TST can provide a sulfane sulfur to GSH, giving rise to the formation of glutathione persulfide (GSSH), a superior antioxidant compared to GSH which can even reduce thioredoxin (TXN

Specifically, it is essential to investigate (i) the critical ROS thresholds that trigger the activation of individual network components and (ii) how these thresholds for specific transcription factors may vary throughout tumorigenesis

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