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(PubMed) How TB-500 Works TB-500 is not full-length TB4 its the N-acetylated 1723 fragment (Ac-LKKTETQ) that corresponds to TB4s actin-binding region

A., Ly, K

However, this strategy is only attractive if the therapeutic agent itself is not a substrate for CPA, or if the case, that its functional activity is not negatively affected by C-terminal cleavage