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This long-term persistence could therefore be because initial effects of TAM are slow to arise and/or indelible (e.g., epigenetic changes), or because they reflect effects of TAM withdrawal rather than TAM itself

The formulations were also investigated for their potential for hair growth and hair follicle viability in cases of secondary alopecia

Primary indications include warfarin reversal (often with PCC for major bleeding) and neonatal prophylaxis against vitamin K deficiency bleeding per NICE NG194

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